MÉTODO IN VITRO PARA EXPRESSAR UM PEPTÍDEO OU PROTEÍNA, MÉTODO PARA FORNECER CÉLULAS COM CARACTERÍSTICAS DE CÉLULAS-TRONCO, MÉTODO PARA FORNECER TIPOS CELULARES DIFERENCIADOS E USO DE RNA

IPC Classification

Priority claims

Abstract

The present invention describes a virus-derived factor which when provided to cells, e.g., by transfecting the cells with RNA encoding the virus-derived factor, enhances expression of RNA encoding a peptide or protein in the cells. In particular, the virus-derived factor enhances survival of cells, in particular when transfected repetitively with RNA, and reduces an IFN response of cells to transfected RNA. Accordingly, the present invention provides methods and means for enhancing expression of RNA in cells. The cells are preferably transfected with the RNA.