MÉTODO PARA DETERMINAR SE UM INDIVÍDUO É AFETADO POR UM CÂNCER, MÉTODO PARA DISCRIMINAR ENTRE CÂNCER COLORRETAL E PANCREÁTICO DENTRE INDIVÍDUOS QUE RESULTAM SER POSITIVOS PARA O MÉTODO, MÉTODO PARA DETERMINAR O ESTÁGIO DE UM CÂNCER COLORRETAL EM UM INDIVÍDUO AFETADO E USO DE UM KIT DE RT-PCR QUANTITATIVO PARA PERFORMAR O MÉTODO

IPC Classification

Priority claims

Abstract

The present invention concerns a method for determining if a subject is affected by a colorectal or pancreatic cancer or for determining the stage and/or the progression of a colorectal cancer. By measuring the presence of a panel of mRNAs encoding for transcription factors/genes involved in epithelial to mesenchymal transition in a blood sample, wherein different mRNA levels of a set of genes comprising TWIST1, SLUG, ZEB2, ZEB1 and CDH1, are indicative of colorectal cancer or pancreatic cancer diagnosis, and/or of colorectal cancer stage at diagnosis, and/or of CRC metastatic progression after surgery. The invention concerns also the use of kits to work the method.